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Caffeine Withdrawal: What 66 Studies Confirm
Caffeine Withdrawal: What 66 Studies Confirm is a comprehensive meta-analysis of 57 experimental and 9 survey studies that empirically validates caffeine withdrawal as a clinical syndrome with 10 primary symptoms including headache, fatigue, and difficulty concentrating. The analysis confirms that withdrawal symptoms typically onset 12-24 hours after abstinence, peak at 20-51 hours, and warrant inclusion as a disorder in the DSM and ICD diagnostic manuals.
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Summary
Caffeine Withdrawal: What 66 Studies Confirm is a comprehensive meta-analysis of 57 experimental and 9 survey studies that empirically validates caffeine withdrawal as a clinical syndrome with 10 primary symptoms including headache, fatigue, and difficulty concentrating. The analysis confirms that withdrawal symptoms typically onset 12-24 hours after abstinence, peak at 20-51 hours, and warrant inclusion as a disorder in the DSM and ICD diagnostic manuals.
Tags
caffeine-withdrawal · meta-analysis · symptom-validation · substance-withdrawal · clinical-research · pharmacology · diagnostic-criteria
Key entities
caffeine-withdrawal-syndrome (concept, 0.99) · substance-withdrawal (concept, 0.95) · DSM (Diagnostic and Statistical Manual of Mental Disorders) (organization, 0.92) · ICD (International Classification of Diseases) (organization, 0.92) · headache (concept, 0.98) · fatigue (concept, 0.98) · NIDA (National Institute on Drug Abuse) (organization, 0.85) · NIH (National Institutes of Health) (organization, 0.9)
Classification
analysis · language en · status final
Provenance
claude-haiku-4-5 via @stacklist/mcp-server@2.0.0, confidence 0.85, 2 Nov 2026