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Higher-Dose Caffeine + L-Theanine: Sharper, Less Tired
This randomized, double-blind, placebo-controlled study examined the cognitive and mood effects of L-theanine (250 mg) and caffeine (150 mg) in isolation and combination. The combination improved reaction time, visual processing accuracy, mental fatigue ratings, and alertness while reducing headaches, suggesting L-theanine and caffeine beverages have a different pharmacological profile than caffeine alone.
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Summary
This randomized, double-blind, placebo-controlled study examined the cognitive and mood effects of L-theanine (250 mg) and caffeine (150 mg) in isolation and combination. The combination improved reaction time, visual processing accuracy, mental fatigue ratings, and alertness while reducing headaches, suggesting L-theanine and caffeine beverages have a different pharmacological profile than caffeine alone.
Tags
caffeine · l-theanine · cognitive-performance · clinical-trial · neuroscience · mood-effects · drug-interaction
Key entities
L-Theanine (concept, 0.99) · Caffeine (concept, 0.99) · Cognitive Performance (concept, 0.95) · Mental Fatigue (concept, 0.93) · Rapid Visual Information Processing (concept, 0.92) · Drug Interaction (concept, 0.9) · Double-Blind Randomized Controlled Trial (technology, 0.94)
Classification
reference · language en · status final
Provenance
claude-haiku-4-5 via @stacklist/mcp-server@2.0.0, confidence 0.85, 2 Nov 2026