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Pharmacokinetic Analysis of Caffeine in Beverages
This research article compares the pharmacokinetics of caffeine (160 mg) administered via coffee and energy drinks under varying temperature and consumption rate conditions in a crossover study design. The study used LC-MS to measure plasma caffeine concentrations and non-compartmental pharmacokinetic analysis to evaluate whether rapid consumption of cold energy drinks produces inordinately high caffeine levels.
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Summary
This research article compares the pharmacokinetics of caffeine (160 mg) administered via coffee and energy drinks under varying temperature and consumption rate conditions in a crossover study design. The study used LC-MS to measure plasma caffeine concentrations and non-compartmental pharmacokinetic analysis to evaluate whether rapid consumption of cold energy drinks produces inordinately high caffeine levels.
Tags
caffeine · pharmacokinetics · energy-drinks · coffee · absorption · clinical-toxicology · beverage-temperature
Key entities
John R. White Jr. (person, 0.99) · Jeannie M. Padowski (person, 0.95) · Philip Lazarus (person, 0.9) · Sterling McPherson (person, 0.9) · Washington State University (organization, 0.99) · Providence Health Care (organization, 0.85) · Spokane, WA (location, 0.98) · caffeine pharmacokinetics (concept, 0.99) · liquid chromatography-mass spectrometry (technology, 0.95) · non-compartmental pharmacokinetic analysis (concept, 0.9)
Classification
reference · language en · status final
Provenance
claude-opus-4-6 via @stacklist/mcp-server@2.0.0, confidence 0.85, 30 Aug 2026