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CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction
CYP1A2 genetic variation modifies the association between coffee intake and kidney dysfunction in individuals with hypertension. Participants with slow caffeine metabolism variants were significantly more likely to develop albuminuria, hyperfiltration, and hypertension complications with heavy coffee consumption.
Built for AI agentsACO · 12703 tokens
Summary
CYP1A2 genetic variation modifies the association between coffee intake and kidney dysfunction in individuals with hypertension. Participants with slow caffeine metabolism variants were significantly more likely to develop albuminuria, hyperfiltration, and hypertension complications with heavy coffee consumption.
Tags
cyp1a2-genotype · coffee-intake · kidney-dysfunction · caffeine-metabolism · hypertension · albuminuria
Key entities
Sara Mahdavi (person, 0.95) · Paolo Palatini (person, 0.95) · Ahmed El-Sohemy (person, 0.95) · University of Toronto (organization, 0.95) · University of Padova (organization, 0.95) · JAMA Network Open (organization, 0.95) · CYP1A2 (technology, 0.95) · caffeine-metabolism (concept, 0.9) · albuminuria (concept, 0.9) · hyperfiltration (concept, 0.9) · Hypertension and Ambulatory Recording Venetia Study (event, 0.85) · Toronto, Ontario, Canada (location, 0.95) · Padova, Italy (location, 0.95)
Classification
analysis · language en · status final
Provenance
claude-haiku-4-5 via @stacklist/be@0.1.0, confidence 0.85, 18 Aug 2026