{"version":"1.0","type":"card","id":"6a589dee-3a13-43bc-a938-000745ef218e","url":"https://stacklist.com/card/6a589dee-3a13-43bc-a938-000745ef218e","title":"Caffeine Withdrawal: What 66 Studies Confirm","source_url":"https://pubmed.ncbi.nlm.nih.gov/15448977/","note":"Landmark review of caffeine withdrawal research: headache and fatigue are the core symptoms, and avoiding them is a major reason people stay hooked on their daily coffee or energy drink.","image":{"url":"https://ucarecdn.com/4543b203-30b6-407f-afb7-989dfe97f1ef/","alt":"Caffeine Withdrawal: What 66 Studies Confirm","width":1500,"height":1001},"stack":{"id":"4dffb12a-725e-4048-883c-4782b5959050","title":"Know Your Dose: LSC100 + Caffeine Dosing & Delivery Guide","url":"https://stacklist.com/c/wellness/stack/4dffb12a-725e-4048-883c-4782b5959050"},"created_at":"2026-11-02T15:21:12.488Z","updated_at":null,"aco":{"summary":"Caffeine Withdrawal: What 66 Studies Confirm is a comprehensive meta-analysis of 57 experimental and 9 survey studies that empirically validates caffeine withdrawal as a clinical syndrome with 10 primary symptoms including headache, fatigue, and difficulty concentrating. The analysis confirms that withdrawal symptoms typically onset 12-24 hours after abstinence, peak at 20-51 hours, and warrant inclusion as a disorder in the DSM and ICD diagnostic manuals.","tags":["caffeine-withdrawal","meta-analysis","symptom-validation","substance-withdrawal","clinical-research","pharmacology","diagnostic-criteria"],"key_entities":[{"name":"caffeine-withdrawal-syndrome","type":"concept","confidence":0.99},{"name":"substance-withdrawal","type":"concept","confidence":0.95},{"name":"DSM (Diagnostic and Statistical Manual of Mental Disorders)","type":"organization","confidence":0.92},{"name":"ICD (International Classification of Diseases)","type":"organization","confidence":0.92},{"name":"headache","type":"concept","confidence":0.98},{"name":"fatigue","type":"concept","confidence":0.98},{"name":"NIDA (National Institute on Drug Abuse)","type":"organization","confidence":0.85},{"name":"NIH (National Institutes of Health)","type":"organization","confidence":0.9}],"classification":"analysis","language":"en","confidence":0.85,"provenance":{"model":"claude-haiku-4-5","tool":"@stacklist/mcp-server@2.0.0","confidence":0.85,"timestamp":"2026-11-02T15:21:19.054Z"},"token_counts":{"approximate":976,"cl100k":798},"content_hash":"sha256:00a4fefac0af90e3007651296e175bff2fbfdeccb9e0b856ca505be74e1595af","acp_version":"0.2","body_available":true,"body_tokens":976,"visibility":"public","agent_accessible":true,"status":"final"},"_links":{"self":"/api/public/card/6a589dee-3a13-43bc-a938-000745ef218e.json","html":"https://stacklist.com/card/6a589dee-3a13-43bc-a938-000745ef218e","md":"/api/public/card/6a589dee-3a13-43bc-a938-000745ef218e.md","stack_json":"/api/public/stack/4dffb12a-725e-4048-883c-4782b5959050.json"}}