{"version":"1.0","type":"card","id":"5fda1e2f-4f62-4d92-a58f-54320bfa5875","url":"https://stacklist.com/card/5fda1e2f-4f62-4d92-a58f-54320bfa5875","title":"OP-BRAI210411 1..16","source_url":null,"note":"Psychedelic drug action is explained through three circuit models: the cortico-striatal thalamo-cortical (CSTC) model, the relaxed beliefs under psychedelics (REBUS) model, and the cortico-claustro-cortical (CCC) model. These models propose that 5-HT2A receptor activation disrupts thalamocortical gating, reduces top-down cortical control, and decouples claustrum-cortex networks, respectively, leading to the diverse neural and subjective effects of psychedelics.","image":{"url":"https://ucarecdn.com/5aaeb23f-8a94-46fe-b7ff-8c1ffd6024fb/","alt":"OP-BRAI210411 1..16","width":1240,"height":1601},"stack":{"id":"3ec64f10-f7d6-4a20-a3c9-499572b61636","title":"Psychedelic Therapy & Integration","url":"https://stacklist.com/c/wellness/stack/3ec64f10-f7d6-4a20-a3c9-499572b61636"},"created_at":"2026-08-23T10:10:50.950Z","updated_at":null,"aco":{"summary":"This paper presents three circuit-level models explaining how psychedelic drugs like psilocybin and LSD affect the brain through serotonin 2A receptor activation, introducing a novel cortico-claustro-cortical model involving the claustrum's role in disrupting canonical cortical networks. The research synthesizes existing models (CSTC and REBUS) while proposing new mechanisms to explain psychedelic drug effects and their potential therapeutic applications for psychiatric disorders.","tags":["psychedelics","neuroscience","serotonin-receptors","brain-circuits","psilocybin","lsd","claustrum"],"key_entities":[{"name":"Manoj K. Doss","type":"person","confidence":0.95},{"name":"Roland R. Griffiths","type":"person","confidence":0.95},{"name":"Frederick S. Barrett","type":"person","confidence":0.95},{"name":"Brian N. Mathur","type":"person","confidence":0.95},{"name":"Johns Hopkins University School of Medicine","type":"organization","confidence":0.98},{"name":"University of Maryland School of Medicine","type":"organization","confidence":0.98},{"name":"serotonin 2A receptor","type":"technology","confidence":0.99},{"name":"cortico-claustro-cortical model","type":"concept","confidence":0.95},{"name":"CSTC model","type":"concept","confidence":0.92},{"name":"REBUS model","type":"concept","confidence":0.92},{"name":"claustrum","type":"concept","confidence":0.97},{"name":"psilocybin","type":"technology","confidence":0.99},{"name":"lysergic acid diethylamide","type":"technology","confidence":0.99},{"name":"Baltimore","type":"location","confidence":0.95}],"classification":"reference","language":"en","confidence":0.85,"provenance":{"model":"claude-haiku-4-5","tool":"@stacklist/be@0.1.0","confidence":0.85,"timestamp":"2026-09-23T10:39:55.874Z"},"token_counts":{"approximate":24739,"cl100k":28300},"content_hash":"sha256:ab9b079be01820b0fc95b2bd73fdffe283b923e551eecf001c3f5cc86ed56e5a","acp_version":"0.2","body_available":true,"body_tokens":24739,"visibility":"public","agent_accessible":true,"status":"final"},"_links":{"self":"/api/public/card/5fda1e2f-4f62-4d92-a58f-54320bfa5875.json","html":"https://stacklist.com/card/5fda1e2f-4f62-4d92-a58f-54320bfa5875","md":"/api/public/card/5fda1e2f-4f62-4d92-a58f-54320bfa5875.md","stack_json":"/api/public/stack/3ec64f10-f7d6-4a20-a3c9-499572b61636.json"}}