{"version":"1.0","type":"card","id":"1da5576e-128a-427b-bf1f-20d634ace7dd","url":"https://stacklist.com/card/1da5576e-128a-427b-bf1f-20d634ace7dd","title":"CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction","source_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9880799/","note":"This study investigates whether genetic variation in CYP1A2 modifies the relationship between coffee consumption and kidney dysfunction. It analyzes data from a cohort of 1180 untreated participants with stage 1 hypertension over a 7.5-year follow-up period.","image":{"url":"https://ucarecdn.com/4c64d6b8-9a09-4470-89e9-1b19f0aacd8e/","alt":"CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction","width":2000,"height":1333},"stack":{"id":"385684d9-7da2-44a5-9f77-c971f5611932","title":"The Chemistry of Calm Energy: LSC100 Caffeine & L-Theanine Science","url":"https://stacklist.com/stack/385684d9-7da2-44a5-9f77-c971f5611932"},"created_at":"2026-08-18T00:41:41.342Z","updated_at":null,"aco":{"summary":"CYP1A2 genetic variation modifies the association between coffee intake and kidney dysfunction in individuals with hypertension. Participants with slow caffeine metabolism variants were significantly more likely to develop albuminuria, hyperfiltration, and hypertension complications with heavy coffee consumption.","tags":["cyp1a2-genotype","coffee-intake","kidney-dysfunction","caffeine-metabolism","hypertension","albuminuria"],"key_entities":[{"name":"Sara Mahdavi","type":"person","confidence":0.95},{"name":"Paolo Palatini","type":"person","confidence":0.95},{"name":"Ahmed El-Sohemy","type":"person","confidence":0.95},{"name":"University of Toronto","type":"organization","confidence":0.95},{"name":"University of Padova","type":"organization","confidence":0.95},{"name":"JAMA Network Open","type":"organization","confidence":0.95},{"name":"CYP1A2","type":"technology","confidence":0.95},{"name":"caffeine-metabolism","type":"concept","confidence":0.9},{"name":"albuminuria","type":"concept","confidence":0.9},{"name":"hyperfiltration","type":"concept","confidence":0.9},{"name":"Hypertension and Ambulatory Recording Venetia Study","type":"event","confidence":0.85},{"name":"Toronto, Ontario, Canada","type":"location","confidence":0.95},{"name":"Padova, Italy","type":"location","confidence":0.95}],"classification":"analysis","language":"en","confidence":0.85,"provenance":{"model":"claude-haiku-4-5","tool":"@stacklist/be@0.1.0","confidence":0.85,"timestamp":"2026-08-18T00:41:47.611Z"},"token_counts":{"approximate":12703,"cl100k":13122},"content_hash":"sha256:46eb3a24900825d10b9e06a2fe8d5089347dcec8cef946af479186ae8e39cc82","acp_version":"0.2","body_available":true,"body_tokens":12703,"visibility":"public","agent_accessible":true,"status":"final"},"_links":{"self":"/api/public/card/1da5576e-128a-427b-bf1f-20d634ace7dd.json","html":"https://stacklist.com/card/1da5576e-128a-427b-bf1f-20d634ace7dd","md":"/api/public/card/1da5576e-128a-427b-bf1f-20d634ace7dd.md","stack_json":"/api/public/stack/385684d9-7da2-44a5-9f77-c971f5611932.json"}}